Propargyl-Gly(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan aldehyde 068 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCC(=O)N2CC3=C(C=CC=C3)C#CC3=C2C=CC=C3)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)

068 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCC(=O)N2CC3=C(C=CC=C3)C#CC3=C2C=CC=C3)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

and bioconjugation

Product Name Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C72H95FN12O23 Molecular Weight 1515

a Azide-Lys(m-PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility

5(6)-FAM PEG3 azide (protected) is an excellent alkyne-reactive fluorescent reagent for labeling azide-containing biological molecules through click chemistry

Propargyl-Gly(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan aldehyde 068 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCC(=O)N2CC3=C(C=CC=C3)C#CC3=C2C=CC=C3)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The