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ACS Chemical Biology
Structural basis for the action of the drug trametinib at KSR-bound MEK
Ready for conjugation to a target protein ligand to form PROTACs containing Lenalidomide as cereblon ligand
S)-AHPC-acetamido-O-PEG4-C2-amine HCl Synonyms CAS Number 2377275-23-3 Related CAS 2377275-22-2 (free base) Molecular Formula C34H54ClN5O9S Molecular Weight 744
making 5(6)-CR6G another color choice for the multicolor fluorescence imaging applications
Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-PNP Size:25mg ACS Chemical BiologySOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The PNP (para
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