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418 SMILES OCCCCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Product Name Phthalimidinoglutarimide-5'-propargyl-PEG2-OH Synonyms CAS Number n/a Related CAS Molecular Formula C20H22N2O6 Molecular Weight 386
Product Name Mal-Propionyl-PEG6-Val-Ala-PAB(m-PEG4)-PNP Synonyms CAS Number Related CAS Molecular Formula C54H79N7O22 Molecular Weight 1178
1038/s41586-020-2760-4
amine-containing groups
Mal-Acetyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-MMAE Size:5mg 418 SMILES OCCCCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate
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