Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE Size:25mg S)-AHPC-acetamido-O-PEG6-OH Synonyms CAS Number n/a

S)-AHPC-acetamido-O-PEG6-OH Synonyms CAS Number n/a Related CAS Molecular Formula C36H56N4O11S Molecular Weight 752

NCCOCCOC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

eLife 2018

the components of the reaction are bioinert

362 SMILES OCCCCC#CC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE Size:25mg S)-AHPC-acetamido-O-PEG6-OH Synonyms CAS Number n/aSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to